Macular degeneration associated with age: symptoms, causes and treatment

Recently we talked about a new treatment for AMD (age-related macular degeneration), which would have several added benefits for the patient: in addition to reversing and significantly improve macular degeneration, and that about 80% only need an intravitreal injection, does not produce side effects.

What is macular degeneration associated with age?

The macular degeneration associated with age (DMAE) is an eye disease caused by degeneration, damage or the deterioration of the macula itself, a yellowish layer of tissue, which is sensitive to light, and which we find in the back of the eye (specifically in the center). of the retina).

This area provides the person with the possibility of perceiving small and fine details, which is why it gives us visual acuity.

So when the degeneration of the macula occurs, these areas of the visual field begin to lose sharpness, being usual that these become turbid and blurry.

Risk factors for macular degeneration associated with age

Although recent publications indicate that the onset of macular degeneration may be due to a mutation of the factor H gene (since patients with this mutation have a lower capacity to control the inflammation caused by any infection), there are a number of risk factor's:

  • Family history of DMAE.
  • Advanced age.
  • Smoking
  • Levels of high cholesterol in blood.

Symptoms of macular degeneration associated with age

Dry or atrophic DMAE

It presents gradual and slow visual loss. But if it affects only one eye, its symptoms may not be noticed by the patient.

Wet or exudative DMAE

It develops with the formation of abnormal blood vessels in the back of the eye, which causes the presentation of a liquid leak, and in turn a distortion of the retina.

Treatment of macular degeneration associated with age

For years, anti-angiogenic drugs have been used, which are injected directly into the vitreous cavity, stabilizing and improving visual acuity, although only in a small percentage of cases. The negative of these treatments are their side effects:

  • Side effects inside the eye: endophthalmitis, retinal detachment, ischemia, cataracts or hemorrhage.
  • Side effects outside the eye: bleeding with intestinal perforation, myocardial or cerebral infarction, hypertension, delay in the healing of wounds and depressions.

As we indicated at the beginning of this article, currently different Spanish specialists are using a revolutionary and novel treatment based on an intravitreal injection based on a vasculotropic treatment -dobesylate-, which continues to reverse and improve the disease without the Side effects of current medical treatments.

The key to this treatment? It acts by inhibiting the growth factor of fibroblasts, which participate in the angiogenesis and inflammation that occurs in the mascular degeneration.

Image | Richard Masoner / Cyclelicious This article is published for informational purposes only. It can not and should not replace the consultation with a Physician. We advise you to consult your Trusted Doctor. ThemesDiseases of the eyes Eyes

Mayo Clinic Minute: Treating age-related macular degeneration (February 2020)